Lecture exploring the large underground scientific infrastructures built to investigate the origins of matter and the universe. Located in extreme geophysical environments, these architectures are not designed for human life but to detect nearly imperceptible phenomena and recreate conditions impossible to achieve on the Earth’s surface. These spaces become sensory infrastructures where scientists, particles, technologies, and data interact within a complex and interconnected ecosystem to generate knowledge. A reflection on the limits of perception, matter, and the ways in which science constructs its own landscapes.